Pangamic Acid (Vitamin B15)
Vitamins
Nutritional Enhancers
20858-86-0
C₁₀H₁₉NO₈
$26.68 ~ $40.02
Food
Free sample from 100g(NF)
One unit of:25kg/barrel
One unit of:25kg/barrel
25kg/barrel
Product Info
What is Pangamic Acid (Vitamin B15)?
Pangamic acid, or Vitamin B15, is a water-soluble compound historically considered a vitamin, though not officially recognized as one, that is primarily used as a dietary supplement marketed for anti-aging and cardiovascular benefits.
How is Pangamic Acid (Vitamin B15) made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Raw Material Preparation | Accurately weigh and charge raw materials, primarily D-gluconic acid and Dimethylglycine (DMG), into a reaction vessel with a suitable solvent. | Purity and identity of all raw materials must be verified via Certificates of Analysis (COA). Strict adherence to the stoichiometric ratio is crucial for reaction efficiency. |
| 2 | Esterification Reaction | Initiate the reaction under controlled conditions to form the ester linkage between the gluconic acid and DMG. | Critical control of reaction temperature, pressure, and time is required to maximize yield and minimize byproduct formation. Reaction progress is monitored using techniques like HPLC or TLC. |
| 3 | Product Isolation & Purification | Isolate the crude Pangamic Acid ester from the reaction mixture, often through precipitation or crystallization. | The choice of solvent and control of the cooling rate are key to achieving high purity and a desirable crystal structure. The product is washed to remove unreacted starting materials and impurities. |
| 4 | Drying | Transfer the purified, wet product to a vacuum dryer to remove all residual solvent and moisture. | Drying must occur at a low, controlled temperature to prevent thermal degradation of the product. The final moisture content must be below the specified limit (e.g., <1.0%). |
| 5 | Milling & Sieving | Mill the dried crystalline product to a uniform powder and pass it through a sieve of a specified mesh size. | This step ensures a consistent particle size distribution, which is important for solubility and blend uniformity in final applications. Equipment must be clean to prevent cross-contamination. |
| 6 | Final Quality Control & Packaging | Sample the final batch for comprehensive testing against specifications. Package the approved product into sealed, labeled containers. | Final QC tests must confirm identity (FTIR), purity (HPLC), and absence of contaminants (heavy metals, microbes). Packaging must be airtight and light-resistant to ensure product stability. |
Technical Specifications
| CAS Number | 20858-86-0 |
| Chemical Formula | C₁₀H₁₉NO₈ |
| Solubility | soluble in water, insoluble in acetone/ether/chloroform |
| Storage Conditions | store dry cool (ideally 2–8 °C) |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
exercise stamina
detox supplements
experimental medicine
Mechanism of action:
| Parameter | Pangamic Acid (Vitamin B15) |
|---|---|
| Functional Category | Antioxidant; Preservative Synergist (Disputed/Unapproved) |
| Key Ingredients | D-gluconodimethylaminoacetic acid |
| Mechanism of Action | Functions as an antioxidant by donating electrons to neutralize free radical species, interrupting lipid peroxidation chain reactions. Acts as a labile methyl group donor in metabolic pathways. Proposed to enhance cellular oxygen uptake, which could theoretically improve the stability of tissues in post-harvest or post-mortem states. |
| Application Effect in Product | Aimed at reducing oxidative rancidity in products containing fats and oils. May help preserve natural color (e.g., myoglobin) and flavor by inhibiting oxidation. Its use as a food additive is not recognized or approved by major regulatory agencies (e.g., FDA, EFSA); primarily found in dietary supplements. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| Pangamic Acid (Vitamin B15) | Dietary Supplement / Pseudovitamin | Not a standardized compound; often contains dimethylglycine (DMG) and calcium gluconate. Claimed to improve cellular oxygenation. | Has a long history of use, particularly in some European countries, for athletic and wellness purposes. | Not a recognized vitamin by medical science. Lacks consistent formulation and robust clinical evidence for its claims. | Individuals experimenting with historical supplement protocols for endurance or general vitality. | If you are specifically seeking the traditional, albeit scientifically unsupported, "B15" formulation based on anecdotal reports. |
| Dimethylglycine (DMG) | Dietary Supplement / Amino Acid Derivative | A standardized chemical compound often found in "B15". An intermediate in choline metabolism. | Provides a consistent, chemically defined product. More scientifically plausible mechanism than the vague "B15" concept. | Clinical evidence for significant performance enhancement is limited and often inconclusive compared to substances like creatine. | General metabolic support, particularly related to methylation and stress reduction. | For a more reliable and pure version of the key ingredient often marketed as Pangamic Acid. |
| Coenzyme Q10 (CoQ10) | Dietary Supplement / Antioxidant | Essential for ATP synthesis (energy production) in mitochondria. A powerful fat-soluble antioxidant. | Extensively researched with proven roles in cellular energy and cardiovascular health. Benefits are well-established. | Generally more expensive. Benefits are systemic and long-term rather than providing an acute performance boost. | Supporting heart health, improving mitochondrial function, and combating age-related energy decline or statin side effects. | For a scientifically-backed, foundational supplement to support cellular energy production at its core. |
| Creatine Monohydrate | Dietary Supplement / Performance Enhancer | Increases phosphocreatine stores in muscles, enabling rapid ATP regeneration for short bursts of effort. | Overwhelmingly supported by decades of scientific research for improving strength, power output, and muscle mass. Very cost-effective. | Primarily benefits anaerobic, high-intensity exercise, not aerobic endurance. Can cause minor water retention. | Strength training, sprinting, and sports requiring repeated bursts of maximal effort. | The gold standard for a legal, safe, and highly effective supplement to boost high-intensity performance and muscle growth. |
| Cordyceps Mushroom | Dietary Supplement / Adaptogen | Contains bioactive compounds like cordycepin. Traditionally used to enhance energy, stamina, and oxygen uptake. | May improve markers of endurance performance (like VO2 max) and fatigue resistance. Offers broader adaptogenic benefits for stress. | Efficacy can vary significantly based on species and extraction method. Research is promising but less conclusive than for creatine. | Endurance sports like running or cycling, improving stamina, and supporting respiratory health. | For a natural, adaptogenic approach to improving aerobic capacity, energy levels, and resilience to fatigue. |
Technical Documents
Available Documentation
CoA, tech sheet
Safety Data Sheet (SDS)
available
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications