Calcium D-pantothenate (Vitamin B5)
Vitamins
Nutritional Enhancers
Minerals & Trace Elements
137-08-6
C₁₈H₃₂CaN₂O₁₀
$8.86 ~ $13.29
Food
Free sample from 100g(NF)
One unit of:25kg/carton
One unit of:25kg/carton
25kg/carton
Product Info
What is Calcium D-pantothenate (Vitamin B5)?
This is the synthetic, stable calcium salt of the essential water-soluble nutrient Vitamin B5, widely incorporated into foods, beverages, and supplements as a nutritional fortifier and dietary supplement.
How is Calcium D-pantothenate (Vitamin B5) made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Raw Material Inspection | Inspect and test key raw materials: Isobutyraldehyde, formaldehyde, β-alanine, and a calcium source (e.g., calcium hydroxide). | Control: Purity, concentration, and identity must meet stringent internal and pharmacopoeial standards. This is foundational for the final product's quality and safety. |
| 2 | Pantolactone Synthesis | Synthesize racemic (D,L)-pantolactone, a key intermediate, through a multi-step reaction involving isobutyraldehyde and formaldehyde. | Control: Precisely manage reaction temperature, catalyst concentration, and pH. In-process checks confirm the completion of this critical intermediate synthesis. |
| 3 | Optical Resolution | Separate the racemic mixture to isolate the biologically active D-(-)-pantolactone isomer from the unwanted L-(+)-isomer, typically using a chiral resolving agent and crystallization. | Control: The specific optical rotation is measured to confirm the purity of the D-isomer. This is the most critical step for ensuring the vitamin's biological efficacy. |
| 4 | Condensation Reaction | React the purified D-(-)-pantolactone with calcium β-alaninate (formed in-situ from β-alanine and a calcium source) in a solvent like methanol to form Calcium D-pantothenate. | Control: Strict control over molar ratios, reaction time, and temperature is essential to maximize yield and minimize the formation of impurities. |
| 5 | Crystallization & Purification | Isolate and purify the crude Calcium D-pantothenate by crystallization from the reaction solvent. The resulting crystals are filtered and washed. | Control: The cooling rate and solvent purity are monitored to ensure high-purity crystal formation and effective removal of residual reactants and by-products. |
| 6 | Drying | Dry the purified wet crystals under vacuum at a controlled low temperature to remove all residual solvents without causing thermal degradation. | Control: Final moisture content must be below the specified limit (e.g., < 5.0%). Product temperature is monitored to prevent discoloration or degradation. |
| 7 | Milling & Sieving | Mill the dried product to achieve a uniform, fine powder. Sieve the powder to ensure it meets the required particle size distribution for better handling and solubility. | Control: Mesh size analysis is performed to verify particle size. Equipment must be meticulously cleaned to prevent cross-contamination. |
| 8 | Final QC & Packaging | Conduct comprehensive analysis of the final powder. Package the approved product into sealed, airtight, and light-resistant containers. | Control: Test against all specifications including Assay (purity), specific rotation, heavy metals, and microbiological limits. Package integrity is crucial for product stability. |
Technical Specifications
| CAS Number | 137-08-6 |
| Chemical Formula | C₁₈H₃₂CaN₂O₁₀ |
| Solubility | soluble in water (~44 mg/ml), DMSO (~44 mg/ml); slightly soluble in ethanol |
| Storage Conditions | store at 2‑8 °C or room temperature, protect from light and moisture |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
dietary supplement
animal feed fortification
cosmetics
pharmaceutical coenzyme-A precursor
cell culture media additive
Mechanism of action:
| Parameter | Calcium D-pantothenate (Vitamin B5) |
|---|---|
| Functional Category | Nutrient Fortificant; Vitamin Supplement |
| Key Ingredients | Calcium D-pantothenate |
| Mechanism of Action | Serves as the biological precursor to Coenzyme A (CoA), an essential cofactor in cellular metabolism. CoA is critical for the synthesis and oxidation of fatty acids, the metabolism of carbohydrates and amino acids (via the Krebs cycle), and the synthesis of neurotransmitters, steroid hormones, and porphyrins. It functions as a carrier of acyl groups, enabling energy production and various anabolic/catabolic pathways. |
| Application Effect in Product | Fortifies foods and beverages to restore nutrient levels lost in processing or to meet specific nutritional claims for Vitamin B5. Contributes to the product's overall nutritional profile as declared on the label. Does not typically impart significant technological or sensory effects on the food matrix. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| Calcium D-pantothenate | Vitamin B5 Salt Form | The stable calcium salt of pantothenic acid; a white powder soluble in water. | Highly stable, cost-effective, and the most common form in dietary supplements and fortified foods. | Less metabolically direct precursor to Coenzyme A compared to Pantethine. | General dietary supplementation for Vitamin B5, food fortification, multivitamin formulations. | For a reliable, standard, and affordable source of Vitamin B5 for general health maintenance. |
| Pantothenic Acid | Vitamin B5 Acid Form | The pure, free acid form of Vitamin B5; a viscous, unstable oil. | It is the direct vitamin molecule, requiring no dissociation from a salt. | Hygroscopic (absorbs moisture) and less stable, making it difficult to use in dry product formulations. | Liquid formulations, scientific research, and laboratory standards. | Rarely chosen for consumer products; primarily for industrial or lab use where stability is controlled. |
| Panthenol | Provitamin B5 (Alcohol) | An alcohol precursor that is converted to pantothenic acid in the body; excellent humectant. | Superior skin and hair penetration for topical use; provides moisturizing and soothing benefits. | As an oral supplement, offers no clear advantage over Calcium D-pantothenate. Racemic (DL) form is only 50% active. | Topical applications in skincare (lotions, creams) and haircare (shampoos, conditioners). | For external use to moisturize, soothe, and repair skin and hair. |
| Dexpanthenol | Active Isomer of Panthenol | The biologically active D-isomer of panthenol. | More potent than racemic panthenol for topical applications as it is 100% biologically active. | More expensive than standard racemic panthenol. | Pharmaceutical preparations, high-performance cosmetics, wound healing ointments, nasal sprays. | For targeted, high-potency topical applications where maximum biological activity is required. |
| Pantethine | Metabolically Active Form | A stable dimer form of pantetheine, a direct precursor to Coenzyme A (CoA). | More direct and efficient in supporting CoA synthesis; clinically studied for lipid metabolism support. | Significantly more expensive; may be unnecessary for addressing simple nutritional deficiency. | Targeted supplementation for supporting healthy cholesterol and triglyceride levels; cardiovascular support. | For specific metabolic goals beyond general vitamin intake, particularly related to lipid management. |
Technical Documents
Available Documentation
COA
Safety Data Sheet (SDS)
Yes
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications