Creatine Monohydrate
Nutritional Enhancers
Amino Acids
6020-87-7
C₄H₁₁N₃O₃·H₂O
$26.68 ~ $40.02
Qualified
Free sample from 100g(NF)
One unit of:25kg/carton
One unit of:25kg/carton
25kg
Product Info
What is Creatine Monohydrate?
Creatine Monohydrate is the most researched and common form of a nitrogenous organic acid used primarily as a food additive and dietary supplement to increase muscle phosphocreatine stores, thereby improving high-intensity exercise performance, strength, and power.
How is Creatine Monohydrate made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Synthesis / Reaction | React sodium sarcosinate with cyanamide in a controlled reactor vessel. | The reaction is typically performed in an aqueous solution. Key controls are temperature, pH, and reactant molar ratio to maximize yield and prevent the formation of impurities. |
| 2 | Crystallization | Cool the reaction mixture gradually to allow creatine monohydrate to crystallize out of the solution. | A slow, controlled cooling rate is crucial. This promotes the growth of large, pure crystals, which are easier to separate and clean in subsequent steps. |
| 3 | Separation | Separate the solid creatine crystals from the liquid mother liquor using a centrifuge or filter. | This step removes the majority of water-soluble impurities and unreacted starting materials. Centrifuge speed and time are monitored for efficient separation. |
| 4 | Washing / Purification | Wash the separated crystals with purified cold water. | Washing removes any remaining impurities from the crystal surfaces. The wash water must be cold to minimize dissolving the creatine product itself. |
| 5 | Drying | Dry the purified, wet crystals under vacuum to remove all residual moisture. | Drying temperature must be kept low to prevent the thermal degradation of creatine into its unwanted byproduct, creatinine. Final moisture content is a critical quality parameter. |
| 6 | Milling & Sieving | Mill the dried creatine to achieve a desired fine particle size (e.g., 200 mesh) and sieve for uniformity. | Milling improves solubility and mouthfeel for the end consumer. Sieving ensures a consistent particle size distribution, which is important for product quality and handling. |
| 7 | Final Quality Control & Packaging | Test the final powder for purity, contaminants, and physical properties before packaging. | High-Performance Liquid Chromatography (HPLC) is used to verify purity is >99%. The product is also tested for contaminants like dicyandiamide (DCD), heavy metals, and microbes. Packaging must be airtight and moisture-proof to ensure product stability. |
Technical Specifications
| CAS Number | 6020-87-7 |
| Chemical Formula | C₄H₁₁N₃O₃·H₂O |
| Solubility | Slightly soluble in water |
| Storage Conditions | Stored in cool, dry and ventilated warehouse, and keep away from moisture. |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
Sports nutrition
cognitive enhancement
neuromuscular disease research
Mechanism of action:
| Parameter | Creatine Monohydrate |
|---|---|
| Functional Category | Ergogenic Aid / Cellular Energizer |
| Key Ingredients | Creatine Monohydrate |
| Mechanism of Action | Increases intramuscular phosphocreatine (PCr) stores, which donate a phosphate group to ADP to rapidly regenerate ATP during high-intensity anaerobic exercise. This enhances the capacity of the ATP-PCr energy system. Also acts as an osmolyte, promoting myocyte hydration and cell volumization. |
| Application Effect in Product | Increased maximal strength and power output; enhanced performance in repeated bouts of high-intensity exercise; supports gains in lean muscle mass and muscle fiber size; may improve recovery between training sets. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| Creatine Monohydrate | Standard Creatine Form | Most researched form (micronized for better solubility); increases muscle ATP for power output. | Highest level of scientific backing for safety and efficacy; most cost-effective per gram. | Lower water solubility can cause gastrointestinal distress or bloating in some users; loading phase often recommended. | General strength, power, and high-intensity sports for athletes at any level. | You want the most proven, reliable, and economical option for improving strength and performance. |
| Creatine Hydrochloride (HCL) | Creatine Salt | Creatine bound to a hydrochloride molecule, increasing its solubility in water. | Superior solubility may reduce stomach discomfort; marketed for smaller serving sizes (micro-dosing). | Significantly more expensive; lacks the extensive research body of monohydrate. | Individuals who experience bloating or stomach issues with monohydrate. | You are willing to pay a premium to minimize potential gastrointestinal side effects. |
| Buffered Creatine (Kre-Alkalyn) | pH-Buffered Creatine | Processed at a higher pH, claimed to be more stable in stomach acid and reduce conversion to creatinine. | Marketed as causing less bloating and water retention; no loading phase is claimed to be necessary. | Much higher cost; independent studies show it is not more effective or stable than monohydrate. | Users sensitive to monohydrate who believe buffering prevents side effects. | You want to try an alternative to monohydrate specifically marketed to reduce bloating, despite a lack of strong evidence. |
| Creatine Magnesium Chelate | Chelate Compound | Creatine chemically bonded to magnesium, protecting it from stomach acid. | Provides magnesium, an essential mineral for energy metabolism; may reduce subcutaneous water retention. | Considerably more expensive; limited research directly comparing performance benefits to monohydrate. | Athletes also focused on magnesium intake or seeking novel creatine forms to test for personal efficacy. | You prioritize the potential synergy of creatine and magnesium and are not sensitive to the high price point. |
| Creatine Ethyl Ester (CEE) | Creatine Ester | An esterified form of creatine, marketed for superior absorption and bioavailability. | Initially claimed to have better absorption and require a smaller dose than monohydrate. | Scientific studies show it is less stable and converts to creatinine more rapidly than monohydrate, making it less effective. | Historically used by those seeking to avoid monohydrate's side effects, but now largely considered an inferior choice based on data. | Not recommended over monohydrate, as research indicates it is less effective for increasing muscle creatine levels. |
Technical Documents
Available Documentation
COA and specification sheet available
Safety Data Sheet (SDS)
MSDS available
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications