Chondroitin Sulfate
Nutritional Enhancers
9007-28-7
(C₁₃H₂₁NO₁₅S)ₙ
$43.31 ~ $64.97
Food
Free sample from 100g(NF)
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Product Info
What is Chondroitin Sulfate?
Chondroitin Sulfate is a sulfated glycosaminoglycan complex naturally present in connective tissue and commercially derived from animal cartilage, primarily used in dietary supplements to support joint health and alleviate symptoms of osteoarthritis.
How is Chondroitin Sulfate made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Raw Material Preparation | Source and prepare animal cartilage (e.g., bovine, porcine, avian). Clean, crush, or grind the cartilage into smaller pieces. | Control Point: Source from certified, healthy animals with full traceability. Note: Proper grinding size is critical for maximizing the surface area for efficient extraction. |
| 2 | Enzymatic Hydrolysis (Extraction) | Mix the prepared cartilage with purified water to form a slurry. Add specific proteolytic enzymes (e.g., papain, alcalase) and heat the mixture. | Control Point: Precisely control temperature, pH, enzyme concentration, and digestion time. Note: This step breaks down the protein matrix, releasing the chondroitin sulfate molecules. Over-digestion can degrade the product. |
| 3 | Filtration & Deproteinization | Filter the hydrolysate to remove solid cartilage residues. Further treat the liquid to precipitate and remove remaining proteins, followed by centrifugation to clarify the solution. | Control Point: Efficiency of solid-liquid separation and protein removal. Note: This is a critical purification step to remove major impurities and prevent them from interfering in later stages. |
| 4 | Decolorization & Fine Filtration | Treat the clarified liquid extract with activated carbon to adsorb color and other impurities. Perform membrane filtration to achieve a clear, particulate-free solution. | Control Point: Amount of activated carbon and contact time. Final solution clarity and color. Note: This step significantly improves the aesthetic quality and purity of the final product. |
| 5 | Alcohol Precipitation (Isolation) | Add a specified concentration of a solvent, typically ethanol, to the purified solution. This causes the chondroitin sulfate to become insoluble and precipitate out as a fibrous solid. | Control Point: Final alcohol concentration and precipitation temperature. Note: This is the primary isolation step. The quality of the precipitate is directly related to the purity of the solution. |
| 6 | Collection & Drying | Collect the precipitated solid material. Wash with alcohol to remove any remaining water-soluble impurities. Dry the product under vacuum at a controlled, low temperature. | Control Point: Final moisture content and drying temperature. Note: Vacuum drying is preferred to prevent thermal degradation of the chondroitin sulfate polymer chains. |
| 7 | Milling & Sieving | Mill the dried, crude product into a fine powder. Sieve the powder through meshes of a specific size to ensure a uniform particle size distribution. | Control Point: Particle size distribution and bulk density. Note: This finishing step ensures the final product is a homogenous powder that meets specifications for formulation and solubility. |
| 8 | Final QC & Packaging | Conduct comprehensive quality control testing on the final powder (e.g., assay, purity, heavy metals, microbial limits) against pharmacopeial standards (USP/EP). Package into airtight, sealed containers. | Control Point: Compliance with all specifications on the Certificate of Analysis (CoA). Note: Rigorous testing is mandatory to ensure product safety, efficacy, and quality. Packaging protects the product from moisture and contamination. |
Technical Specifications
| CAS Number | 9007-28-7 |
| Chemical Formula | (C₁₃H₂₁NO₁₅S)ₙ |
| Solubility | Soluble in water (~50 mg/mL) |
| Storage Conditions | Cool, dry, <25 °C, under inert gas |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
Dietary supplements
osteoarthritis support
skincare
tissue engineering
Mechanism of action:
| Parameter | Chondroitin Sulfate |
|---|---|
| Functional Category | Structural Component; Joint Health Agent; Nutraceutical; Viscosifier |
| Key Ingredients | Chondroitin Sulfate (a sulfated glycosaminoglycan composed of repeating disaccharide units) |
| Mechanism of Action | Serves as a primary structural component of cartilage aggrecan, providing osmotic pressure and resistance to compression; inhibits cartilage-degrading enzymes (e.g., metalloproteinases); provides substrate for the synthesis of new proteoglycans and hyaluronic acid; exhibits anti-inflammatory properties by modulating cellular signaling pathways. |
| Application Effect in Product | Used in dietary supplements to support joint comfort, mobility, and flexibility; helps maintain cartilage structure and function over time; contributes to the viscosity and lubrication of synovial fluid; may be used in nutricosmetics to support skin hydration and elasticity. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| Chondroitin Sulfate | Glycosaminoglycan Supplement | A major structural component of cartilage; helps cartilage retain water and elasticity. | Extensive research, especially when combined with glucosamine; directly supports cartilage structure and integrity. | Variable absorption due to large molecule size; benefits can take several weeks to months to become apparent. | Long-term management of mild to moderate osteoarthritis; slowing cartilage degradation. | For a foundational, well-studied approach to preserving existing cartilage structure. |
| Glucosamine Sulfate | Amino Sugar Supplement | A natural building block for creating cartilage, specifically glycosaminoglycans. | One of the most researched supplements for osteoarthritis; good evidence for pain relief and slowing joint space narrowing. | Often derived from shellfish, posing an allergy risk; benefits are not immediate. | Mild to moderate osteoarthritis; supporting cartilage synthesis and repair. | To provide the essential building blocks needed to maintain and repair cartilage. |
| MSM (Methylsulfonylmethane) | Organosulfur Compound | A source of sulfur, which is critical for forming collagen and other connective tissues; has anti-inflammatory properties. | Offers both pain relief via anti-inflammatory action and provides a key mineral for tissue health. | Less direct evidence for cartilage rebuilding compared to glucosamine/chondroitin. | Joint pain accompanied by inflammation; supporting overall connective tissue health (hair, skin, nails). | For its dual action on reducing inflammation and supplying sulfur for tissue repair. |
| Hyaluronic Acid (Oral) | Glycosaminoglycan Supplement | A primary component of synovial fluid, responsible for lubricating joints. | Directly supports joint lubrication and shock absorption; may offer faster relief for stiffness. | Oral bioavailability has been a subject of debate, though newer formulations show better absorption. | Osteoarthritis with symptoms of joint stiffness, grinding, or decreased lubrication. | To specifically target the health and viscosity of the joint's lubricating fluid. |
| UC-II (Undenatured Type II Collagen) | Patented Collagen Supplement | Works through a unique immune-mediated process called oral tolerance to reduce cartilage degradation. | Requires a very small daily dose (around 40mg); effective for both osteo and rheumatoid arthritis symptoms. | Functions more to prevent breakdown than to rebuild; can be more expensive as a branded ingredient. | Joint discomfort driven by inflammation and cartilage breakdown from physical activity or arthritis. | For a low-dose, targeted approach that modulates the immune response to protect joints. |
| Boswellia Serrata | Herbal Extract | Contains boswellic acids, which are potent natural anti-inflammatory agents. | Provides strong, relatively fast-acting pain and inflammation relief; a plant-based alternative. | Does not provide structural building blocks for cartilage; its focus is on symptom management. | Managing acute or chronic joint pain and inflammation to improve mobility and comfort. | For a powerful, natural anti-inflammatory to manage pain and improve joint function quickly. |
Technical Documents
Available Documentation
Technical datasheet, COA provided
Safety Data Sheet (SDS)
SDS available
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications