Calcium Citrate Malate
Nutritional Enhancers
Minerals & Trace Elements
Acidity Regulators
142606-53-9
C₁₆H₁₄Ca₄O₁₉·5H₂O
$3.46 ~ $5.19
Food
Free sample from 100g(NF)
One unit of:25kg/bag
One unit of:25kg/bag
25kg/bag
Product Info
What is Calcium Citrate Malate?
Calcium Citrate Malate is a highly bioavailable, water-soluble calcium salt derived from citric and malic acids, primarily used in supplements and fortified foods to promote bone health.
How is Calcium Citrate Malate made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Raw Material Preparation | Accurately weigh and prepare raw materials: a Calcium Source (typically Calcium Carbonate), Citric Acid, Malic Acid, and Purified Water. | Control Point: All raw materials must be of a specified grade (e.g., Food Grade) and verified against their Certificate of Analysis (CoA) for purity, identity, and absence of contaminants. |
| 2 | Reaction & Chelation | Create an aqueous solution of Citric Acid and Malic Acid. Slowly add the Calcium Carbonate to the acid solution under continuous agitation to form the Calcium Citrate Malate complex. | Control Point: Monitor and control the reaction temperature (e.g., 60-80°C) and pH level. Slow addition of the calcium source is critical to manage CO2 evolution and prevent foaming. Reaction completion is verified by a stable pH. |
| 3 | Filtration | Pump the reacted slurry through a filtration system (e.g., filter press) to remove any unreacted solids or insoluble impurities. | Control Point: The resulting filtrate must be a clear and transparent solution. Regular checks on filter integrity prevent particulate carryover. |
| 4 | Spray Drying | Atomize the clear Calcium Citrate Malate solution into a hot air stream within the spray dryer chamber. The water rapidly evaporates, leaving a fine powder. | Control Point: Critical control of inlet and outlet air temperatures is essential. This directly influences the final product's moisture content, particle size, and bulk density. |
| 5 | Sieving & Blending | Pass the collected powder through a vibrating sieve to ensure a uniform and specified particle size distribution. Blend different batches if required for homogeneity. | Control Point: Verify the correct sieve mesh size is used to meet product specifications. Ensure equipment is thoroughly cleaned to prevent any cross-contamination. |
| 6 | Final Quality Control | Take representative samples from the final batch and perform a full analysis in the laboratory. | Control Point: Testing must confirm compliance with all specifications, including Calcium content, Citrate to Malate ratio, solubility, pH, heavy metals (Pb, As, Cd), and microbiological limits. Product is held until all tests pass. |
| 7 | Packaging & Storage | Package the approved final product into sealed, moisture-proof, food-grade containers or bags in a clean and controlled environment. | Control Point: Ensure packaging integrity to protect against moisture and contamination. Verify accurate labeling with batch number, manufacturing date, and expiration date. Store in a cool, dry place. |
Technical Specifications
| CAS Number | 142606-53-9 |
| Chemical Formula | C₁₆H₁₄Ca₄O₁₉·5H₂O |
| Solubility | soluble in water; insoluble in alcohol |
| Storage Conditions | store in a cool, dry, and well-ventilated area |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
used as a calcium supplement in functional foods
beverages
and dietary supplements
Mechanism of action:
| Parameter | Calcium Citrate Malate |
|---|---|
| Functional Category | Bioavailable Calcium Source; Nutritional Fortificant |
| Key Ingredients | Calcium Citrate Malate (A complex of calcium, citric acid, and malic acid) |
| Mechanism of Action | Forms a highly soluble, chelated complex that remains stable across a wide intestinal pH range. This solubility prevents calcium from precipitating with dietary inhibitors (e.g., oxalates, phytates), maximizing its availability for passive and active absorption in the small intestine. The citrate-malate ligand is metabolized, releasing calcium ions for uptake. |
| Application Effect in Product | Provides effective calcium fortification in beverages and foods with minimal impact on taste or texture. Enhances nutritional value without causing cloudiness, sedimentation, or gritty mouthfeel often associated with less soluble calcium salts. Contributes to bone health claims on product labels. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| Calcium Citrate Malate | Chelated Calcium Salt | A calcium compound bound to citric and malic acids; contains about 21-26% elemental calcium. | Highest bioavailability; can be taken with or without food; gentle on the stomach. | More expensive; lower elemental calcium content by weight than carbonate. | Individuals with low stomach acid, older adults, or those taking acid-reducing medications. | For superior, food-independent absorption and minimal digestive side effects. |
| Calcium Carbonate | Simple Calcium Salt | Most common and inexpensive form; contains the highest concentration of elemental calcium (40%). | Cost-effective; highest elemental calcium per tablet, requiring fewer pills. | Requires stomach acid for absorption (must be taken with food); may cause gas and constipation. | Budget-conscious users with normal stomach acid who can take it with meals. | For the highest dose of calcium per pill at the lowest cost. |
| Calcium Citrate | Organic Acid Salt | Calcium bound to citric acid; contains 21% elemental calcium. | Well-absorbed; can be taken with or without food; less likely to cause side effects than carbonate. | Lower elemental calcium than carbonate, requiring a larger dose; more expensive than carbonate. | A good alternative to carbonate for those with sensitive stomachs or low stomach acid. | For good absorption without food and better digestive tolerance than carbonate. |
| Calcium Gluconate | Organic Acid Salt | Contains a low concentration of elemental calcium (about 9%). | Very gentle on the digestive system and well-tolerated. | Very low elemental calcium content requires taking a large number of tablets for a therapeutic dose. | Often used in medical settings (IV) or for very minor dietary supplementation. | When extreme gentleness is the priority over dosage convenience. |
| Calcium Lactate | Organic Acid Salt | Contains about 13% elemental calcium; derived from lactic acid. | Absorbed easily and does not require a highly acidic environment; gentle on the stomach. | Low elemental calcium concentration means more pills are needed to achieve the desired dose. | People who find calcium carbonate constipating or have absorption issues. | As a gentle, well-absorbed option that is less constipating than carbonate. |
Technical Documents
Available Documentation
spec sheets and monographs available
Safety Data Sheet (SDS)
MSDS available
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications