L-Lysine Hydrochloride (L-Lysine HCl)
Amino Acids
Nutritional Enhancers
Flavoring Agents
657-27-2
C₆H₁₄N₂O₂·HCl
$1.94 ~ $2.91
Food
Free sample from 100g(NF)
One unit of:25kg/bag
One unit of:25kg/bag
25kg/bag
Product Info
What is L-Lysine Hydrochloride (L-Lysine HCl)?
L-Lysine Hydrochloride is the stable salt form of the essential amino acid L-lysine, widely utilized in nutritional supplements and animal feed as a crucial component for protein synthesis and growth.
How is L-Lysine Hydrochloride (L-Lysine HCl) made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Medium Preparation | Formulate and sterilize the fermentation medium by mixing a carbon source (e.g., corn starch, glucose), nitrogen source, minerals, and water. | Control Point: Precise ratio of nutrients, pH, and complete sterilization temperature/time. Note: The medium composition is a critical factor for achieving a high fermentation yield. |
| 2 | Seed Culture Development | Inoculate a small amount of a high-yielding microbial strain (e.g., Corynebacterium glutamicum) into a seed fermenter to grow a robust starter culture. | Control Point: Purity of the microbial strain and strict aseptic transfer techniques to prevent contamination. Note: A healthy and active seed culture is essential for successful main fermentation. |
| 3 | Main Fermentation | Transfer the seed culture to a large-scale industrial fermenter. The microorganisms consume the nutrients in the medium to produce L-Lysine over several days. | Control Point: Continuous monitoring and control of pH, temperature, dissolved oxygen (DO), and agitation. Note: This is the core bioconversion step. Maintaining optimal conditions is crucial for maximizing product synthesis. |
| 4 | Broth Harvesting & Cell Separation | Harvest the fermentation broth. Separate the microbial cells and solid impurities from the L-Lysine-rich liquid broth. | Control Point: Efficiency of the separation method (e.g., centrifugation, microfiltration) to obtain a clear, cell-free supernatant. Note: Incomplete separation can lead to impurities in later stages. |
| 5 | Ion-Exchange Purification | Pass the clear broth through a cation-exchange chromatography column. L-Lysine binds to the resin while impurities are washed away. Elute the purified L-Lysine from the resin. | Control Point: Column flow rate, pH of the broth and eluent, and resin regeneration. Note: This is the primary purification step that significantly increases the product's purity. |
| 6 | Concentration & Neutralization | Concentrate the purified L-Lysine solution via vacuum evaporation. Add Hydrochloric Acid (HCl) to neutralize the solution and form the L-Lysine Hydrochloride salt. | Control Point: Precise pH adjustment (typically to ~5.0-5.5) with HCl. Controlled temperature during evaporation to prevent degradation. Note: This step converts L-Lysine into its more stable and crystallizable salt form. |
| 7 | Crystallization | Cool the concentrated L-Lysine HCl solution under controlled conditions to induce the formation of crystals. Separate the crystals from the remaining liquid (mother liquor). | Control Point: Controlled cooling rate to ensure desired crystal size and purity. Efficient separation via centrifugation. Note: The mother liquor may be reprocessed to improve overall yield. |
| 8 | Drying & Sieving | Dry the wet crystals in a fluid-bed dryer to remove residual moisture. Sieve the dried product to achieve a uniform particle size distribution. | Control Point: Drying temperature and time to reach the target moisture content (typically <1.0%). Correct sieve mesh size. Note: Proper drying is crucial for product stability and shelf-life. |
| 9 | Quality Control & Packaging | Conduct final quality analysis for purity, heavy metals, and microbiological content. Package the finished L-Lysine HCl into sealed, moisture-proof containers. | Control Point: Final product must meet pharmacopeia or food-grade standards (e.g., USP, FCC). Accurate weighing and proper sealing of packages. Note: Proper packaging ensures product integrity during storage and transportation. |
Technical Specifications
| CAS Number | 657-27-2 |
| Chemical Formula | C₆H₁₄N₂O₂·HCl |
| Solubility | Freely soluble in water; practically insoluble in alcohol and ether |
| Storage Conditions | Cool, dry, avoid moisture |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
Food/beverage supplement
animal feed additive
pharmaceuticals
Mechanism of action:
| Parameter | L-Lysine Hydrochloride (L-Lysine HCl) |
|---|---|
| Functional Category | Nutrient Fortifier; Amino Acid Supplement; Flavor Enhancer; Dough Conditioner. |
| Key Ingredients | L-Lysine Monohydrochloride (C₆H₁₅ClN₂O₂). |
| Mechanism of Action | Provides the essential amino acid L-lysine, which is often limiting in cereal proteins, to improve the overall protein quality of the food. The primary amine group participates in Maillard reactions with reducing sugars during thermal processing to generate savory flavor compounds (e.g., pyrazines) and brown pigments (melanoidins). In baking, it can strengthen the gluten network by forming cross-links. |
| Application Effect in Product | Increases the Protein Efficiency Ratio (PER) and biological value of foods like bread, pasta, and plant-based alternatives. Enhances surface browning and develops savory, roasted flavor profiles in baked goods, snacks, and seasonings. Improves dough handling, fermentation tolerance, and loaf volume in some yeast-leavened products. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| L-Lysine Hydrochloride (L-Lysine HCl) | Amino Acid Salt Supplement | L-Lysine bound to a hydrochloride salt to enhance stability and solubility. | Very stable, highly water-soluble, widely available, and typically the most cost-effective form. | Lower lysine concentration by weight (~80%) compared to free form. Adds chloride to the diet. | General daily supplementation, dissolving powder into liquids, users prioritizing stability and cost. | You want the standard, most affordable, and chemically stable form of L-Lysine for everyday use. |
| L-Lysine (Free Form) | Amino Acid Supplement | Pure L-Lysine amino acid without any attached salt. | Higher potency of lysine by weight. Avoids intake of additional chloride. | Less stable, may be more hygroscopic (absorbs moisture), and can be more expensive or harder to find. | Individuals seeking maximum lysine purity per dose or wanting to avoid the chloride component of L-Lysine HCl. | You prioritize the highest concentration of pure lysine and want to avoid the associated salt. |
| L-Lysine Acetate | Amino Acid Salt Supplement | L-Lysine bound to an acetate salt. | Alternative salt form for those who may be sensitive to hydrochloride; good solubility. | Much less common as an over-the-counter oral supplement; primarily used in clinical/IV settings. Often more expensive. | Medical formulations like parenteral nutrition, or as a specific oral alternative to the HCl form if required. | You need a non-chloride salt form for specific medical or digestive reasons. |
| Lysine with Vitamin C & Zinc | Combination Supplement | A formula combining L-Lysine with other immune-supporting nutrients. | Offers a synergistic, multi-ingredient approach to immune health in a single product; convenient. | Fixed nutrient ratios may not be ideal for all users; lysine dose per serving may be lower than in pure products. | Supporting overall immune function, particularly during periods of stress or for managing viral issues like cold sores. | You want the convenience of a combined formula for broad immune support rather than taking several individual supplements. |
Technical Documents
Available Documentation
COA, MSDS, technical certificate
Safety Data Sheet (SDS)
Provided
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications