L-Glutamine
Amino Acids
Nutritional Enhancers
Flavoring Agents
56‑85‑9
C₅H₁₀N₂O₃
$2.81 ~ $4.21
Food
Free sample from 100g(NF)
One unit of:25KG/DRUM
One unit of:25KG/DRUM
25KG/DRUM
Product Info
What is L-Glutamine?
L-Glutamine is the most abundant conditional essential amino acid in the body, utilized as a high-purity nutritional ingredient in food and dietary supplements to support intestinal integrity, muscle recovery, and metabolic function.
How is L-Glutamine made?
| Step No. | Production Stage | Key Action | Control Point & Note |
|---|---|---|---|
| 1 | Medium Preparation & Sterilization | Prepare a liquid medium containing a carbon source (e.g., glucose), a nitrogen source (e.g., ammonia), minerals, and growth factors. Sterilize the medium at high temperature and pressure. | Control Point: Sterilization time, temperature, and pressure. Note: Complete sterility is absolutely critical to prevent contamination by unwanted microbes, which would lower the yield and introduce impurities. |
| 2 | Fermentation | Inoculate the sterile medium with a high-producing microbial strain (e.g., Corynebacterium glutamicum). Culture the microbes in a large-scale fermenter under controlled conditions. | Control Point: pH, temperature, dissolved oxygen, and nutrient feeding rate. Note: These parameters are tightly controlled to maximize the metabolic production of L-Glutamine by the microorganisms. |
| 3 | Cell Separation | After fermentation is complete, separate the microbial cells from the L-Glutamine-rich fermentation broth using centrifugation or microfiltration. | Control Point: Centrifuge speed or filter membrane pore size. Note: The goal is to achieve a clear, cell-free broth with minimal loss of the dissolved L-Glutamine product. |
| 4 | Purification (Ion Exchange) | Pass the clarified broth through an ion-exchange chromatography column. L-Glutamine binds to the resin while impurities are washed away. Elute the purified L-Glutamine from the column. | Control Point: pH, flow rate, and eluent concentration. Note: This is the primary purification step responsible for removing other amino acids, salts, and colored impurities. |
| 5 | Concentration & Crystallization | Concentrate the purified L-Glutamine solution by evaporating water under a vacuum. As the solution becomes supersaturated, L-Glutamine crystallizes out. | Control Point: Vacuum level and temperature. Note: Using a vacuum allows for evaporation at a lower temperature, which prevents thermal degradation of the sensitive L-Glutamine molecule. |
| 6 | Drying | Separate the L-Glutamine crystals from the remaining liquid (mother liquor) via centrifugation. Dry the crystals in a vacuum or fluidized bed dryer. | Control Point: Drying temperature and final moisture content. Note: Proper drying is essential to ensure product stability and shelf-life. The final moisture level is a key quality specification. |
| 7 | Sieving & Packaging | Sieve the dried L-Glutamine powder to ensure a uniform and specified particle size. Package the final product into sealed, food-grade, multi-layer bags or drums. | Control Point: Sieve mesh size and packaging integrity. Note: This step ensures the product meets physical specifications and is protected from moisture and contaminants. Accurate labeling for lot traceability is crucial. |
Technical Specifications
| CAS Number | 56‑85‑9 |
| Chemical Formula | C₅H₁₀N₂O₃ |
| Storage Conditions | Cool, dry, dark; solution at –20 °C |
| Shelf Life | 24 Months |
Applications & Usage
Common Applications:
Food/feed additive
dietary supplements
cell culture media
pharmaceuticals
Mechanism of action:
| Parameter | L-Glutamine |
|---|---|
| Functional Category | Flavor Enhancer; Nutrient Source; Cell Culture Medium Component. |
| Key Ingredients | L-Glutamine (C5H10N2O3), a non-essential amino acid. |
| Mechanism of Action | As a flavor agent, it contributes to the umami taste by stimulating taste receptors. As a nutrient, it serves as a primary metabolic fuel for rapidly dividing cells (e.g., enterocytes, lymphocytes), a precursor for nucleotide synthesis, and a key component in the synthesis of the antioxidant glutathione. |
| Application Effect in Product | Enhances savory notes and mouthfeel in processed foods, broths, and seasonings. Fortifies medical foods, infant formulas, and sports nutrition products to support gut integrity and immune function. Acts as a critical energy source in cell culture media for biotechnological production. |
Comparison:
| Product Name | Category/Type | Key Features | Strengths (vs peers) | Weaknesses (vs peers) | Best Use Cases | Why Choose |
|---|---|---|---|---|---|---|
| L-Glutamine | Conditionally Essential Amino Acid | Supports gut lining integrity, immune function, and muscle recovery. Most abundant amino acid in plasma. | Excellent for direct support of gut health and the immune system. Generally inexpensive and widely available. | Less potent for directly stimulating muscle protein synthesis compared to BCAAs or whey protein. | Supporting gut health during stress, aiding immune function during intense training periods, reducing muscle soreness. | Your primary goals are gut integrity and immune support, with muscle recovery as a secondary benefit. |
| Glutamine Peptides | Peptide-Bonded Amino Acid | L-Glutamine molecules bonded to other amino acids, designed for improved stability and absorption. | Potentially more stable in liquids and more bioavailable than free-form L-Glutamine. | Often more expensive. May be derived from sources containing allergens like wheat (gluten). | Individuals seeking potentially enhanced absorption or who experience digestive upset with free-form glutamine. | You want the benefits of glutamine with potentially better stability and are willing to pay a premium. |
| BCAAs (Branched-Chain Amino Acids) | Essential Amino Acid Supplement | Contains Leucine, Isoleucine, and Valine. Directly involved in muscle protein synthesis. | Directly stimulates the mTOR pathway for muscle growth (especially Leucine). Can reduce central fatigue during exercise. | Lacks the specific gut health and immune support benefits of L-Glutamine. Can be redundant if protein intake is high. | Intra-workout consumption to reduce muscle breakdown and fatigue; kickstarting recovery post-workout. | Your primary focus is directly stimulating muscle growth, preserving lean mass, and reducing exercise fatigue. |
| Creatine Monohydrate | Performance Enhancer Supplement | Increases intramuscular phosphocreatine stores, aiding in ATP regeneration for explosive energy. | Highly researched and proven to increase strength, power output, and muscle mass. Very cost-effective. | Does not provide the gut or immune benefits of L-Glutamine. Can cause initial water weight gain. | Improving performance in high-intensity, short-duration activities like weightlifting and sprinting. | You want a proven, direct way to increase strength, power, and overall lean muscle mass. |
| Whey Protein | Complete Protein Source | Fast-digesting dairy-based protein containing all essential amino acids, including BCAAs and glutamine. | Provides a full spectrum of amino acids needed for muscle repair and growth in one product. Highly effective post-workout. | Not a targeted supplement; it's a food source with calories. Can cause issues for the lactose intolerant (unless an isolate). | Post-workout recovery shake; supplementing daily protein intake to meet muscle-building or dietary goals. | You need a comprehensive solution to increase total daily protein for muscle repair and growth. |
Technical Documents
Available Documentation
COA, MSDS, technical data, USP certificate
Safety Data Sheet (SDS)
Provided
Certificate of Analysis (COA)
Quality assurance documentation
Technical Data Sheet
Detailed technical specifications